Hydroxyurea was embryotoxic and teratogenic in rats and rabbits at doses 0.8 times and 0.3 times, respectively, the maximum recommended human daily dose on a mg/m
Patients on stable hydroxyurea doses continued the drug throughout the trial. Randomization was stratified by whether the patient was already receiving hydroxyurea, by geographic region, and by age.
Our data suggest that adults should be treated with the maximum tolerated hydroxyurea dose, ideally before organ damage occurs, study
Clinical response to hydroxyurea therapy may take 3 to 6 months; a 6-month trial on the maximum tolerated dose is required prior to considering discontinuation
hydroxyurea (HU) maximum restarting dose: chart-pv-restarting-dosing. aContinue treatment for
Figure 1 illustrates a time line for hydroxyurea treatment in this patient population, beginning with early proof-of-principle studies in adults. In the early 2024s, an important prospective phase 1/2 study in adults 15 using hydroxyurea at maximum tolerated dose (MTD) was followed by the pivotal NHLBI-sponsored double-blinded
Patients on stable hydroxyurea doses continued the drug throughout the trial. Randomization was stratified by whether the patient was already receiving hydroxyurea, by geographic region, and by age.
Normal time averaged mean maximum velocities (TAMMV) in these The use of hydroxyurea, the dose of hydroxyurea, and the presence of
Typically, the maximum dose that I recommend for patients with polycythemia vera is about 2 grams of hydroxyurea per day over 3 months. I wouldn
That said, keep up the story-telling. I'll be watching for part 2.