Nitroprusside cyanide toxicity

Sodium thiosulfate and hydroxocobalamin have both been empirically used for cyanide toxicity and have specifically been evaluated for cyanide toxicity associated with sodium nitroprusside. Cobinamide is an investigational agent currently being evaluated for efficacy and safety in the treatment of cyanide toxicity.

Warnings: Excessive hypotension and cyanide toxicity are significant risks of nitroprusside Treatment of cyanide toxicity: Discontinue sodium nitroprusside

Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity [see WARNINGS AND PRECAUTIONS] or as thiocyanate toxicity [see

Warnings: Excessive hypotension and cyanide toxicity are significant risks of nitroprusside Treatment of cyanide toxicity: Discontinue sodium nitroprusside

Cyanide toxicity is a rare complication of sodium nitroprusside that can be difficult to diagnose in critically ill patients. We describe a case of cyanide toxicity after cardiac surgery that presented as lactic acidosis after discontinuation of nitroprusside.

Nitroprusside Cyanide Toxicity is due to the cyanide groups released from metabolism of the nitroprusside molecule. After gaining an electron from the iron moiety of hemoglobin, the sodium nitroprusside produces an unstable radical and methemoglobin.

Page 18. Nitroprusside Induced Cyanide Toxicity. Molecule: 5 cyanide radicals, gradually released, occasionally produce cyanide or thiocyanate toxicity.

Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous

An early manifestation of cyanide toxicity is increasing dosage requirements to maintain blood pressure control. Metabolic acidosis may not be evident for more than an hour after toxic cyanide levels accumulate. If cyanide toxicity develops, discontinue sodium nitroprusside, and consider specific treatment of cyanide toxicity [see Overdosage ].