Captopril and enalapril are approved for infants and children; however, lisinopril is only approved for 7 years of age. This study evaluated safety and efficacy of converting from captopril to lisinopril in patients utilizing a pre-defined conversion of 3 mg captopril to 1 mg lisinopril.
Angiotensin converting enzyme (ACE) inhibitors, such as lisinopril, enalapril, ramipril, benazepril, and captopril, block the conversion of
A captopril conversion rate of 3 mg captopril to 1 mg lisinopril was used. This study demonstrated that utilizing a conversion rate of 3 mg of captopril to 1 mg of lisinopril can be considered safe and effective for management of hypertension after cardiothoracic surgery in children less than 7 years of age.
OBJECTIVE:To provide clinical support that conversion from Captopril to lisinopril at a daily oral dosage ratio of 5:1 maintains comparable therapeutic efficacy, and to estimate retrospectively cost savings because of conversion from Captopril to lisinopril therapy at the study site and with the associated overall drug conversion program instituted by Kaiser Permanente.DESIGN:An open-label
lisinopril once blood pressures have stabilized. Based on anecdotal and historical experiences at our center, the current practice when converting captopril to lisinopril is to utilize a conversion rate of 3 mg captopril to 1 mg lisinopril. The decision to historically utilize a 3:1 conversion was largely due to ease of converting given cap -
Angiotensin converting enzyme (ACE) inhibitors, such as lisinopril, enalapril, ramipril, benazepril, and captopril, block the conversion of
A captopril conversion rate of 3 mg captopril to 1 mg lisinopril was used. This study demonstrated that utilizing a conversion rate of 3 mg of captopril to 1 mg of lisinopril can be considered safe and effective for management of hypertension after cardiothoracic surgery in children less than 7 years of age.
A synthesis was not conducted by the authors since lisinopril therapy was a weakly dominant strategy. The conversion from captopril (in
Most angiotensin converting enzyme inhibitors are prodrugs, requiring hepatic conversion to an active metabolite. Captopril and lisinopril are
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