The evidence for the interaction is so overwhelming, the FDA published labeling changes in the prescribing information for Plavix warning against taking it with omeprazole: Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix.
a potential drug interaction between clopidogrel Drug interactions: Co-administration of Plavix with omeprazole, a proton pump inhibitor.
Plavix (clopidogrel) patients should be Leading cardiologists challenge clinical importance of interaction between clopidogrel (Plavix) and omeprazole
Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (
Plavix (clopidogrel) patients should be Leading cardiologists challenge clinical importance of interaction between clopidogrel (Plavix) and omeprazole
Prilosec OTC (omeprazole) and Plavix (clopidogrel). While clinically significant interactions between warfarin or digoxin and omeprazole are unlikely, the
omeprazole (Prilosec). If you're taking one of the drugs listed above Plavix and coffee (not an interaction). Plavix doesn't interact with coffee
There is no interaction between grapefruit or grapefruit juice and omeprazole. Plavix (clopidogrel); Dextromethorphan; Digoxin; Estrogen
omeprazole (Prilosec). If you're taking one of the drugs listed above Plavix and coffee (not an interaction). Plavix doesn't interact with coffee
Hence Omeprazole being a much more expensive drug than it is now.....