The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole [Prilosec] or esomeprazole [Nexium]. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix. Plavix Prescribing Information
Omeprazole can reduce the effectiveness of Plavix, an antiplatelet drug, and increase the risk of cardiovascular events. Learn how omeprazole inhibits the liver enzyme CYP2C19 that transforms Plavix and what alternatives to consider.
The evidence for the interaction is so overwhelming, the FDA published labeling changes in the prescribing information for Plavix warning against taking it with omeprazole: Omeprazole, a moderate CYP2C19 inhibitor, reduces the pharmacological activity of Plavix.
The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole [Prilosec] or esomeprazole [Nexium]. Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix. Plavix Prescribing Information
Avoid concomitant use of Plavix and drugs that inhibit CYP2C19 activity. Co‑administration of Plavix with omeprazole, a proton pump inhibitor that is an
Antihistamine And Omeprazole Together (Plavix)com/omeprazole/what-you-may-not-know-about-omeprazole bcgd Taking
Avoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavix [see Drug Interactions (
omeprazole; pantoprazole; prednisone; tramadol; trazodone Plavix, respectively), and Methocarbamol and Plavix (the brand names).
Omeprazole can reduce the effectiveness of Plavix, an antiplatelet drug, and increase the risk of cardiovascular events. Learn how omeprazole inhibits the liver enzyme CYP2C19 that transforms Plavix and what alternatives to consider.
Hence Omeprazole being a much more expensive drug than it is now.....