Two randomized trials compared short-course regimens of valacyclovir administered for prodromal symptoms for one day (2 g twice daily) or two days (2 g twice daily on the first day and 1 g twice daily on the second day) . Valacyclovir shortened outbreaks by approximately one day compared with placebo; treatment for one day was as effective as
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Patients receiving treatment in this study took either 2,000 mg of valacyclovir twice a day for one day or 2,000 mg of valacyclovir twice a day for one day then 1,000 mg twice a day the next day.
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