Hydroxyzine has a QT prolongation warning in Europe. Diphenhydramine does not. Which [of these two] medications is more likely to prolong QT?
by T Welzel 2024 Cited by 12No clear association between antihistamines and QT prolongation, TdP Levocetirizine does not prolong the QT/QTc interval in healthy subjects:
Consider an alternative drug that does not cause QT prolongation OR monitor QT Amiodarone. Bretylium. Disopyramide. Dronedarone. Flecainide. Procainamide.
Diphenhydramine (Benadryl): For allergies Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?.
Hydroxyzine has a QT prolongation warning in Europe. Diphenhydramine does not. Which [of these two] medications is more likely to prolong QT?
Consider an alternative drug that does not cause QT prolongation OR monitor QT Aripiprazole. Amisulpride. Chlorpromazine. Lithium. Anticholinergic drugs.
Hydroxyzine has a QT prolongation warning in Europe. Diphenhydramine does not. Which [of these two] medications is more likely to prolong QT?
Hydroxyzine has a QT prolongation warning in Europe. Diphenhydramine does not. Which [of these two] medications is more likely to prolong QT?
○ Prolonged QT interval (hydroxyzine, diphenhydramine) or risk factors for QT prolongation (hydroxyzine doses ≥100mg) – such as concomitant QT prolonging
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