Nitroprusside cyanide toxicity

Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (

Warnings: Excessive hypotension and cyanide toxicity are significant risks of nitroprusside Treatment of cyanide toxicity: Discontinue sodium nitroprusside

Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.

Nitroprusside Cyanide Toxicity is due to the cyanide groups released from metabolism of the nitroprusside molecule. After gaining an electron from the iron moiety of hemoglobin, the sodium nitroprusside produces an unstable radical and methemoglobin.

cyanide toxicity or as thiocyanate toxicity. o Standard Cyanide treatment is often effective. Sodium nitroprusside infusions at rates

SODIUM NITROPRUSSIDE STRENGTHENED CYANIDE TOXICITY WARNING has been adopted by Abbott and Hoffmann-La Roche, marketers of sodium nitroprusside under the

exposure or in a patient with suspicion of cyanide toxicity (eg: Unexplained, Prevention of Nitroprusside Induced Cyanide Toxicity.

Sodium nitroprusside and cyanide poisoning. Nitroprusside and cyanide toxicity. Sodium nitroprusside is a medication used in the management of acute

Sodium thiosulfate and hydroxocobalamin have both been empirically used for cyanide toxicity and have specifically been evaluated for cyanide toxicity associated with sodium nitroprusside. Cobinamide is an investigational agent currently being evaluated for efficacy and safety in the treatment of cyanide toxicity.