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Author: Admin | 2025-04-28
Brand Names Associated with Propranolol Inderal® Inderal® LA Inderal® XL Inderide® (as a combination product containing Hydrochlorothiazide, Propranolol) Inderide® LA (as a combination product containing Hydrochlorothiazide, Propranolol) InnoPran® InnoPran® XL Pronol® Propranolol (Cardiovascular) Brand Names Associated with Rizatriptan Maxalt-MLT® Maxalt® Rizatriptan Medical Content Editor Last updated Nov 19, 2023 Curious for more information about this interaction? Ask our pharmacists directly! Reach out to us Interaction Effect Increased rizatriptan exposure Interaction Summary Concomitant use of propranolol and rizatriptan has resulted in increased rizatriptan AUC and Cmax values. The mechanism of action for this interaction is unknown; however, it is postulated that inhibition of monamine oxidase A by propranolol increases concentrations of rizatriptan. Administration of propranolol with rizatriptan may also lead to increased propranolol blood levels and/or toxicity . In adults treated with propranolol, rizatriptan 5 mg (maximum of 3 doses in a 24-hour period) is recommended. In pediatric patients treated with propranolol, only a single 5 mg dose of rizatriptan is recommended (maximum dose 5 mg within 24 hours). Rizatriptan should not be administered in propranolol-treated pediatric patients weighing less than 40 kg . Also, since propranolol increases the exposure of rizatriptan and dosage adjustment is not possible with rizatriptan oral film, concomitant use of rizatriptan oral film with propranolol is contraindicated . Severity Contraindicated Onset Rapid Evidence Established How To Manage Interaction Concomitant use of propranolol and rizatriptan has resulted in increased rizatriptan plasma concentrations. Therefore, in adults treated with propranolol, rizatriptan 5 mg (maximum of 3 doses in a
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