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Author: Admin | 2025-04-28
On seizure threshold with other opioids. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present.Grapefruit - While grapefruit is not psychoactive, it may affect the metabolism of certain opioids. Tramadol, oxycodone, and fentanyl are all primarily metabolized by the enzyme CYP3A4, which is potently inhibited by grapefruit juice[13]. This may cause the drug to take longer to clear from the body. it may increase toxicity with repeated doses. Methadone may also be affected[13]. Codeine and hydrocodone are metabolized by CYP2D6. People who are on medicines that inhibit CYP2D6, or that lack the enzyme due to a genetic mutation will not respond to codeine as it can not be metabolized into its active product: morphine.Psychedelics - Methadone is known to lower the seizure threshold[citation needed] and psychedelics may act as triggers for seizures in those who are susceptible to them.Serotonin syndrome riskWhile methadone has been reported to occasionally cause serotonin syndrome when combined with certain substances (such as those listed below), anecdotal reports suggests that it does so at a much lower rate than tramadol.Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.MAOIs - Such as banisteriopsis caapi, syrian rue, phenelzine, selegiline, and moclobemide.[14]Serotonin releasers - Such as MDMA, 4-FA, methamphetamine, methylone and αMT.SSRIs - Such as citalopram and sertralineSNRIs - Such as tramadol and venlafaxine5-HTPLegal statusThis legality section is a stub.As such, it may contain incomplete or wrong information. You can help by expanding it.Canada: Methadone is a Schedule I Controlled Substance.[15]Germany: Methadone is a controlled substance under Anlage III of the BtMG. It can only be prescribed on a narcotic prescription form.[16]Russia: Methadone is a Schedule I controlled substance.[17]Switzerland: Methadone is a controlled substance specifically named under Verzeichnis A. Medicinal use
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