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Author: Admin | 2025-04-28
Lexapro Generic Name & Formulations General Description Escitalopram (as oxalate) (single-isomer citalopram) 5mg, 10mg+, 20mg+; tabs (+scored). Pharmacological Class SSRI. See Also How Supplied Tabs—100; Soln—contact supplier Storage Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15 to 30°C (59° to 86°F). Manufacturer Mechanism of Action The mechanism of antidepressant action of escitalopram, the S-enantiomer of racemic citalopram, is presumed to be linked to potentiation of serotonergic activity in the CNS resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT). Lexapro Indications Indications Generalized anxiety disorder. Lexapro Dosage and Administration Adult Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 1 week. Elderly or hepatic impairment: 10mg once daily. Children Lexapro Contraindications Contraindications During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue. Lexapro Boxed Warnings Boxed Warning Suicidality and antidepressant drugs. Lexapro Warnings/Precautions Warnings/Precautions Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic impairment: see Adult and Children Dosage. Renal impairment (CrCl rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor. Lexapro Pharmacokinetics Absorption Absolute bioavailability: ~80%.Peak blood levels occur at ~5 hours. Distribution Volume of distribution: ~12 L/kg.Plasma protein bound: ~56%. Elimination Half-life: ~27–32 hours.Oral clearance: 600 mL/min. Lexapro Interactions Interactions See
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