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Author: Admin | 2025-04-28
Harder stools and less frequent and less effective defecation.To prevent OIC, laxatives must be started at the same time as opioid therapy. If OIC is not prevented, it can be treated with both pharmacological and non-pharmacological therapies. Non-pharmacological treatments include increasing dietary fibre, fluid intake, and physical exercise. Pharmacological treatments include a range of over-the-counter and prescription medications.Over-the-counter medications include stimulant laxatives, stool softeners, and enemas. Stimulant laxatives irritate sensory nerve endings to stimulate colonic motility and reduce colonic water absorption. Stool softeners, such as docusate sodium, are surfactants that allow water and lipids to penetrate the stool, hydrating and softening it. Lubricants, such as mineral oil, soften the stool and lubricate the lining of the gut. Osmotic laxatives, such as polyethylene glycol, draw water into the gut to hydrate the stool.Prescription medications for OIC include lubiprostone, methylnaltrexone, naloxegol, and naldemedine. Lubiprostone is a chloride channel activator that increases fluid secretion in the GI tract, resulting in increased tone, enhanced peristalsis, and accelerated small bowel and colonic transit times. Methylnaltrexone is a peripherally acting opiate antagonist that does not cross the blood-brain barrier, thereby avoiding symptoms of opioid withdrawal. Naloxegol and naldemedine are also peripherally acting mu-opioid receptor antagonists that do not interfere with the analgesic effects of opioids.Frequently asked questions Laxatives are not listed as a cause of erectile dysfunction. However, constipation can cause erectile dysfunction, and laxatives are used to treat constipation. The most common types of medication that are linked to erectile dysfunction include antidepressants, anti-ulcer drugs, tranquilizers, and diuretics. According to Ayurveda, a natural remedy for erectile dysfunction is to drink warm milk with a teaspoon of ghee at night. Talk to your doctor or healthcare provider. Do not stop taking any medication without first seeking advice from a medical professional.
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